Where to Get Profhilo (BAP) at a Reputable Clinic in Ho Chi Minh City: 5 Points per Side and Recovery

Get Profhilo (BAP) at a clinic licensed by the Department of Health, where a doctor with a practising certificate examines you in person, injects 5 points on each side of the face and opens the product box in front of you. Most people return to normal activities the same day. BonBoz Clinic (66–68 Võ Văn Tần, Xuân Hòa Ward (formerly District 3), Ho Chi Minh City) offers this service. The Ho Chi Minh City Department of Health has issued the clinic two operating licences: 11113/HCM-GPHĐ (Dermatology) and 10036/HCM-GPHĐ (Aesthetics). The examination and injection are performed by Dr. Bùi Thị Kim Kha, Specialist Level I (practising certificate 009784/ĐL-CCHN).

This article is for people who have heard of Profhilo and are looking for somewhere to have it done. It explains what the product is and what it can do, why it is called a "5-point" injection, what happens during a session, how soon you can get back to normal, how it differs from Jalupro, and eight things to check before you book. For a detailed explanation of how the technique works, see BAP technique — HA skin remodelling. Sources for all medical figures are listed at the end.

What is Profhilo, and what is BAP?

Profhilo is the brand name of an injectable hyaluronic acid (HA) product made by IBSA (Italy). According to published sources, each 2 ml syringe contains 32 mg of high-molecular-weight HA and 32 mg of low-molecular-weight HA. The two types of HA are heat-treated to form stable "hybrid complexes", instead of being chemically cross-linked as most HA fillers are. For this reason, Profhilo is often described as a high-concentration, heat-stabilised "hybrid" HA.

The key difference from fillers is that Profhilo gel has low viscosity and is designed to spread through the tissue after injection rather than stay in one spot. It is not used to shape the nose or chin, or to fill hollow cheeks. Its goal is skin quality: hydration, elasticity and firmness.

BAP stands for Bio Aesthetic Points, a technique in which the product is injected at a set of fixed points on the face specified by the manufacturer. When clients ask for "BAP Profhilo", they usually mean Profhilo injected with this technique. The same technique can also be used with other products. At BonBoz, BAP is available with Profhilo, Karisma and Ejal40, and the doctor chooses the product after examining you.

What can Profhilo do, and what can't it do?

The most frequently cited study is a 2016 trial of 64 women in Italy, published in Clinical, Cosmetic and Investigational Dermatology. Each participant had 2 sessions 4 weeks apart and was followed up until week 16. The authors recorded a smoother skin surface and better surface hydration from week 4. Deep-layer hydration, wrinkles and cheek hollowing (scored by the doctor) showed statistically significant improvement from week 8. By week 16, roughness and wrinkles measured by instrument had fallen by about 8–10% from baseline (Sparavigna and Tenconi, 2016).

These figures should be kept in perspective: the study had no control group and was funded by the product's distributor. A smaller study of 11 women (Laurino et al., 2015) also recorded better hydration and elasticity after 2 sessions. The results show the direction of the effect (more hydrated, smoother and slightly firmer skin), not a promise for any individual.

What Profhilo cannot do: lift clearly sagging tissue, erase the dynamic wrinkles that appear when you smile or frown, or reshape the face and restore volume as a filler does. If the skin has loosened considerably, the doctor may discuss other options such as HIFU or a thread lift. Dynamic wrinkles are treated with muscle-relaxing injections, not HA.

How many points and how many sessions does BAP Profhilo involve?

Five points on each side of the face, ten points in total. According to a 2025 review of safety data by authors affiliated with the manufacturer, the Profhilo instructions for use specify the BAP technique: injection into the deep dermis–superficial subcutaneous layer with a 29G needle, a small 0.2 ml bolus at each point, and five points on each side across the cheekbone and below-cheekbone area. Ten points × 0.2 ml equals exactly one 2 ml syringe for the whole face. The needle and dose given here follow the manufacturer's instructions; each person's exact injection plan is decided by the doctor after the examination.

The 2016 study describes the five points as: the prominence of the cheekbone, the area beside the nasal ala, the lower border of the tragus (in front of the ear), the area along the line from the corner of the mouth down to the chin, and the angle of the jaw. BonBoz's BAP method page uses more familiar names for these landmarks: cheekbone, below the cheekbone, in front of the ear, jaw angle and chin. According to the manufacturer's instructions, the product spreads from these points into the surrounding area. Fixed positions do not mean zero risk: vascular occlusion remains a rare event (see the recovery section), so the doctor marks each point on your own face rather than following a generic template.

Number of sessions: according to the same 2025 review, the recommended course is 2 injections 30 days apart. About 2 months after the last one, you return for a follow-up assessment and, if needed, maintenance injections about 2 months apart. The doctor decides whether maintenance is needed based on your skin at each follow-up.

Who is Profhilo suitable for, and who should avoid it?

Usually suitable: adults whose skin is starting to thin, dry out and lose elasticity with age, with mild sagging of the cheeks or jawline, who want better skin quality across the whole face without changing its shape. It can also be considered as a complement before or after a course of non-surgical lifting.

Should not be injected, or should postpone:

• Pregnancy or breastfeeding (the 2016 study excluded this group, and there are no safety data for pregnancy).
• Infection, inflamed acne, pustules or open wounds in the area to be treated.
• A previous allergy or unusual reaction to HA or dermal fillers.
• Active autoimmune disease or a bleeding disorder.
• Blood-thinning medication (including daily aspirin): do not stop it on your own; tell the doctor, who will consider the timing of the injection.
• A goal of clear reshaping, volume restoration or lifting: Profhilo will not achieve this.

Everyone's medical history is different. That is why, before injecting, the doctor must ask what medication you take, what allergies you have had, whether you have any chronic conditions, and what has been injected into your face before, where and when.

What happens during a Profhilo session?

1. 1Examination and history: the doctor assesses hydration, firmness, degree of sagging and skin thickness, asks the questions listed above, then tells you plainly whether Profhilo suits you and what you can realistically expect.
2. 2Standardised photos: taken so results can be compared at the follow-up, rather than judged by feel.
3. 3Cleansing and topical numbing: makeup removal, disinfection, and numbing cream for about 20 minutes.
4. 4Opening the product: the sealed box is opened in front of you, and you have the right to see the name, batch number and expiry date.
5. 5Marking and injecting: the doctor marks five points on each side and slowly injects an equal amount at each point. The injection itself usually takes about 15–20 minutes.
6. 6Aftercare instructions and second appointment: what to avoid for the first few days, warning signs that mean you should call back, and the date of the next session about 4 weeks later.

How long is recovery after Profhilo?

Most people go back to work and normal activities the same day, following the doctor's instructions. The most noticeable effect is small bumps at the ten injection points, because the gel needs time to spread into the tissue. According to BonBoz's BAP method page, these bumps usually settle within 1–3 days. The same page advises no makeup for the first 12 hours and no steam rooms or strenuous exercise for 2–3 days, as summarised in the table below. In the Sparavigna and Tenconi (2016) study, 14% of participants had mild bruising and 7.8% had mild swelling at the injection points, both resolving within about 3–10 days. Laurino et al. (2015) recorded bruising after about 12% of injections, which resolved within 2–3 days. These figures come from studies abroad, not from BonBoz's own data.

See a doctor immediately if you notice any of these signs: the skin around an injection point turns pale, cold, bluish or mottled; severe pain, or pain that gets worse instead of easing; blurred vision or eye pain; hot, red swelling with fever or discharge; a rash spreading across the body, or difficulty breathing. The review by Salti et al. (2025) found vascular events to be rare: 1 report each of embolism and occlusion among an estimated more than 1 million people who had Profhilo injected into the face between 01/2018 and 10/2023, and the authors attributed both to incorrect injection technique. An earlier review of data from the product's first 3 years on the market (Cassuto et al., 2020) recorded 12 adverse event reports, none of them serious, mostly swelling, oedema, redness and bruising at the injection site. Rare does not mean never, so the injection must be performed by a doctor, and the clinic must have a procedure for managing complications.

How do Profhilo and Jalupro differ?

These two names often come up together because both are injectables that improve skin quality, but they differ in composition and approach:

• Profhilo (IBSA, Italy): contains only HA, in two molecular weights (high and low), stabilised by heat. The instructions for use specify the BAP technique, with five points on each side of the face.
• Jalupro (Professional Derma, Switzerland): a product range that combines a blend of amino acids with HA. The manufacturer describes it as amino acid replacement therapy to stimulate collagen production. According to the manufacturer's website, the Classic version combines the amino acids with low-molecular-weight HA, the HMW version combines them with high-molecular-weight HA, and other versions target the eye area and deeper tissue structure.

This article does not say which product works better, because we do not have a reliable head-to-head comparison of the two. The right question is what your skin is lacking, and the doctor chooses based on that. At BonBoz, the products available with the BAP technique are Profhilo, Karisma and Ejal40. If the main goal is surface hydration, the doctor may suggest a hydrating skin booster, a different technique that delivers micro-injections into the dermis.

How to choose a safe clinic for Profhilo in Ho Chi Minh City

People often search with a district name: Tan Binh, Binh Thanh, Go Vap, Thu Duc, District 7. Distance matters, because the course needs at least two injections about 4 weeks apart plus a follow-up visit, so choose somewhere you can return to on schedule. The safety criteria, however, are the same in every district:

1. 1A licensed clinic: ask for the Department of Health operating licence number, check the specialty stated on it (dermatology or aesthetics), and make sure the address on the licence matches the premises you are in. Profhilo injection is a medical procedure; spas and beauty salons are not permitted to perform it.
2. 2Know who will inject you: ask in advance for the full name and practising certificate number of the doctor.
3. 3A genuine examination, not just a sales pitch for a package: your history is taken, your skin is examined, and the doctor is willing to say "you don't need this yet" when that is the case.
4. 4A transparent product: a sealed box opened in front of you, with the name, batch number and expiry date visible. One Profhilo syringe for the face is 2 ml, matching ten points × 0.2 ml.
5. 5Correct technique: the doctor marks the injection points according to your anatomy and explains why each one is chosen.
6. 6A written quote after the examination, stating the product, the number of injections and whether the follow-up is included in the price.
7. 7No guaranteed results: promises such as "ten years younger" or "a surgical-style lift" are not backed by any study.
8. 8A phone number you can call after the injection, and a follow-up appointment with the date written down.

How much does Profhilo cost?

At BonBoz, skin boosters and BAP are priced per session. How the price is calculated, and what makes it vary, is explained on the page cost of mesotherapy, skin booster and BAP. Your total cost also depends on the product the doctor chooses, the number of sessions in the course and the treatment area (face only, or neck as well), so the doctor gives you a written quote for the rest after the examination. Comparing two quotes is only meaningful when both state the product name, the number of injections and whether the follow-up visit is charged.

The clinic's promotions change from time to time, so ask about the current offer when you book.

Profhilo at BonBoz Clinic

BonBoz Clinic offers Profhilo injections using the BAP technique as part of its non-surgical aesthetic medicine services. Dr. Bùi Thị Kim Kha, Specialist Level I (practising certificate 009784/ĐL-CCHN), examines you, assesses your skin quality and degree of sagging, chooses the product (Profhilo, Karisma or Ejal40) and personally performs the injection. If your skin has sagged beyond what a skin-quality injection can address, the doctor will tell you so rather than let you spend money on the wrong treatment.

The clinic is at 66–68 Võ Văn Tần, Xuân Hòa Ward (formerly District 3), Ho Chi Minh City. Copies of its two operating licences from the Ho Chi Minh City Department of Health, 10036/HCM-GPHĐ for Aesthetics and 11113/HCM-GPHĐ for Dermatology, are published on the Operating licence page.

Frequently Asked Questions

How much does BAP Profhilo cost?

At BonBoz, skin boosters and BAP are priced per session. How the price is calculated is explained on the page cost of mesotherapy, skin booster and BAP. The doctor gives you the figure that applies to you in writing after the examination, based on the chosen product, the number of injections and the treatment area.

How many points are injected with Profhilo?

Ten points across the whole face: five on each side, 0.2 ml per point, following the BAP technique in the manufacturer's instructions. The points lie in the cheekbone and below-cheekbone area, and the doctor marks them according to each person's anatomy.

What does Profhilo do?

Profhilo targets skin quality: more hydrated, smoother skin with slightly better elasticity and firmness. In the 2016 study, improvement began to be recorded between week 4 and week 8. It does not reshape the face, does not restore volume as a filler does, and cannot lift clearly sagging skin.

How soon can I go back to work after Profhilo?

Most people go back to work the same day. The bumps at the injection points usually settle within 1–3 days. In the 2016 study, any mild bruising or swelling resolved within about 3–10 days. If you have an important event coming up, allow for those 10 days when you book.

How do Profhilo and Jalupro differ?

Profhilo contains only HA in two molecular weights, stabilised by heat, and is injected at five points on each side. Jalupro is a product range that combines a blend of amino acids with HA. Their compositions differ, and the doctor chooses based on your skin, not the brand name. At BonBoz, the products available with the BAP technique are Profhilo, Karisma and Ejal40.

Does BAP come with a free HIFU session?

That depends on the promotion running at the time, so ask the clinic when you book. HIFU and BAP are two different methods: HIFU uses focused ultrasound energy to improve firmness, while BAP uses HA injections to improve skin quality. Whether to combine them is for your doctor to recommend after the examination, not something decided by a package.

How often do I need repeat injections?

The recommended course is 2 sessions about 30 days apart, followed by a review about 2 months after the last one. If needed, maintenance injections are given about once every 2 months. How often you need repeats depends on your skin.

Should foreigners or short-term visitors to Ho Chi Minh City have Profhilo?

Plan ahead: the course needs 2 sessions about 4 weeks apart, plus a follow-up visit. If you already know you will not be able to come back, tell the doctor at the first consultation so you can decide together whether it makes sense to start the course now. When you book, ask the clinic which languages are available for the consultation.

References

• Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clinical, Cosmetic and Investigational Dermatology, 2016;9:297–305: full text on PubMed Central.
• Laurino C, Palmieri B, Coacci A. Efficacy, safety, and tolerance of a new injection technique for high- and low-molecular-weight hyaluronic acid hybrid complexes. Eplasty, 2015;15:e46: full text on PubMed Central.
• Cassuto D et al. Safety Assessment of High- and Low-Molecular-Weight Hyaluronans (Profhilo®) as Derived from Worldwide Postmarketing Data. BioMed Research International, 2020: PubMed 32685528.
• Salti G et al. Hyaluronic Acid Hybrid Cooperative Complexes Nearing 10 Years of Use: Update on Safety Assessment Based on Post-Marketing Surveillance Data. Journal of Cosmetic Dermatology, 2025;24(7):e70197: full text on PubMed Central.
• Professional Derma SA — introduction page for the Jalupro injectable product range: jalupro.com.

A note on the sources: the clinical studies of Profhilo are all small and uncontrolled, and some of the authors work for, or are funded by, the manufacturer.

*Last updated: 11/11/2026. This content is intended to help you prepare for a consultation; whether to have an injection, and with which product, is decided by the doctor after examining your skin in person.*